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From The New England Journal of Medicine The discovery of prostate-specific antigen (PSA), a serine protease, was one of the most important accomplishments in urologic oncology in the past 15 years. In a relatively short time and in an extraordinary way, this tumor marker affected virtually all medical and surgical aspects of prostate cancer, the most prevalent malignant neoplasm in men. Today, the PSA test is an essential tool for screening, early detection, staging, definition of outcome, selection of treatment, assessment of therapeutic effects, and determination of overall prognosis. The strengths of Prostate Specific Antigen are in its coverage of the history of PSA, the various immunoassays for PSA, PSA density and velocity

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